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Examples ofgabapentin
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Routine care consisted primarily ofgabapentin, amitriptyline, and venlafaxine.
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In summary, amitriptyline and carbamazepine are more cost-effective than tramadol andgabapentinand should be considered as first-line treatment for neuropathic pain in patients free of renal or cardiovascular disease.
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Gabapentinis a sodium channel blocker, in common with other drugs used to treat neuropathic pain.
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Gabapentinhas a relatively benign side effect profile.
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Other medications that are used to reduce pain includegabapentin, carbamazepine, or tricyclic antidepressants such as amitriptyline.
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This example is from Wikipedia and may be reused under a CC BY-SA license.This study aimed to compare the effectiveness and safety ofgabapentincombined with an opioid versus opioid monotherapy for the management of neuropathic cancer pain.
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Early treatment of mice was also employed in studies using celecoxib andgabapentin.
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This result is supported by the correlation of the anti-allodynic effect ofgabapentinand the reduction of microglia activation.
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The traditional anticonvlusants are rarely useful and limited by side effects, butgabapentinmay be a second line therapy98 (no trial evidence to date).
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Postherpetic neuralgia,14 painful diabetic neuropathy15 and, more recently, neuropathic cancer pain16 have all been successfully managed usinggabapentin.
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Reversal of allodynia was of similar magnitude to that observed withgabapentinand enhanced efficacy was observed in combination.
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Gabapentinis not metabolized or protein bound, and does not alter hepatic enzymes or interact with other anticonvulsants.
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Although the initial randomized trials excluded patients who had not responded to previousgabapentintreatment at dosages 1200 mg/day, later studies allowed such patients to be enrolled.
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Gabapentinhad shown efficacy similar to other new drugs in regulatory trials.
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Gabapentinwas the most expensive as well as the least beneficial.
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Treatment often requires adjuvant analgesics, includinggabapentin, to complement the effects of opioids.
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