histone modification

collocation in English

meaningsofmodification

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modification
noun
uk
/ˌmɒd.ɪ.fɪˈkeɪ.ʃən/us
/ˌmɑː.də.fəˈkeɪ.ʃən/
a change to something, usually to ...
See more atmodification

(Definition ofmodificationfrom theCambridge English Dictionary© Cambridge University Press)

Examplesofhistone modification

These examples are from corpora and from sources on the web. Any opinions in the examples do not represent the opinion of the Cambridge Dictionary editors or of Cambridge University Press or its licensors.
Pioneer factors can play a role in this by binding specific enhancers and flagginghistonemodificationenzymes to that specific gene.
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Thishistonemodificationis used as a marker of promoters, using it to map these elements in the human genome.
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Methylation, along withhistonemodification, is central to imprinting.
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Histonemodificationis now considered a major regulatory mechanism that is involved in many different stages of genetic functions.
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In some cases, similar processes associated withhistonemodificationhave been observed to transcriptionally upregulate genes.
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The choice of telomere maintenance mechanism may be influenced through epigenetic mechanisms and changes in histone modifications, possibly during tumourigenesis.
From theCambridge English Corpus
To a large extent, differences in transcription factor binding are determined by the chromatin accessibility of their binding sites throughhistonemodificationand/or pioneer factors.
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However, in perennial, iteroparous relatives thehistonemodificationrapidly disappears when temperatures rise, allowing expression of the floral inhibitor to increase and limiting flowering to a short interval.
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The pore-forming activity is not involved in causing the histone modifications.
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The collective set of histone modifications in a given cell is known as the histone code.
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Studies on histone modifications may reveal many novel therapeutic targets.
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Because the sub-field of histone modifications is relatively new, there aren't many results yet.
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Recent provocative studies point to a key function of chromatin structure and histone modifications in alternative splicing regulation.
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Differing histone modifications are likely to function in differing ways; acetylation at one position is likely to function differently from acetylation at another position.
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Pioneer factors can also be associated with recruiting transcription-activating histone modifications.
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Based on the "histone code" hypothesis, distinct covalent histone modifications can lead to functionally distinct chromatin structures that influence the fate of the cell.
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Later, this idea was almost forgotten, until the experimental evidence has indicated a possible role of covalent histone modifications as an epigenetic code.
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A recent study of about 40 histone modifications across human gene promoters found over 4000 different combinations used, over 3000 occurring at only a single promoter.
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The second category is histone modifications.
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Deimination regulates gene expression through histone modifications.
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These examples are from corpora and from sources on the web. Any opinions in the examples do not represent the opinion of the Cambridge Dictionary editors or of Cambridge University Press or its licensors.
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