Delayed emesis can persist up to five days aftercisplatinadministration, peaking in intensity at 48 to 72 hours.
From theCambridge English Corpus
This balanced perspective on the impact of this novel could increase capacity in a service stretched to provide adequatecisplatinprovision.
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The firstcisplatinanalog to be developed was carboplatin.
From theCambridge English Corpus
The toxicity profile mirrored that ofcisplatinalone with the most common toxicities being cytopenias (n 10), nausea/vomiting (n 9), and asthenia (n 5).
From theCambridge English Corpus
Clinical trials have since establishedcisplatinin lung, ovarian, esophageal, cervical, head and neck and germ cell cancers.
From theCambridge English Corpus
For this reason,cisplatin-induced emesis has become the human model by which antiemetic regimens are evaluated (7).
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Like other traditional chemotherapeutic agents,cisplatinhas untoward side-effects (nephrotoxicity, ototoxicity, and neuropathy) and clinical drug resistance does occur.
From theCambridge English Corpus
T he drugs best known t o cause anosmia arecisplatinand neuroleptic drugs.
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Acute emesis usually begins 2 to 4 hours aftercisplatinadministration and peaks at 6 hours (23;26).
From theCambridge English Corpus
Unfortunately, carboplatin shows a marked degree of cross-resistance when compared tocisplatin.
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Epidermal growth factor receptor pathway analysis identifies amphiregulin as a key factor forcisplatinresistance of human breast cancer cells.
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The results of our study show thatcisplatinhas no effect on either minisatellite mutations or crossover frequencies during the most important stages of mouse spermatogenesis.
From theCambridge English Corpus
In the case of antineoplastic agents such as paclitaxel,cisplatinand thalidomide, the neuropathy is dose-dependent and doselimiting; patients often cannot tolerate the doses necessary to treat the underlying cancer.
From theCambridge English Corpus
Carboplatin costs £205.71 against £17.90 forcisplatin, but the total treatment costs are reduced from £347.90 to £228.77.
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This research is especially useful for cancer patients because chemotherapy drugs, such ascisplatin, cause nausea and vomiting.
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