The development of both types of ligands could therefore have important biomedical implications.From theCambridge English Corpus
Studies such as presented here can serve to provide the data necessary for application of opioid ligands in such unique settings.From theCambridge English Corpus
The sharing of these receptors by multiple cytokines raises the question of how the ligands can trigger specific responses in the target cells.From theCambridge English Corpus
Thus, the net effect of the mixture of the two ligands at the level of the whole animal will be the combined effect.From theCambridge English Corpus
The latter may either cooperate in binding heme or might bind distinct ligands.From theCambridge English Corpus
Our data in conjunction with those of other laboratories indicates the differences in orientation of different ligands within the same binding cleft.From theCambridge English Corpus
Polycystin-1 comprises multiple extra- and intracellular protein domains that suggest many different protein ligands and hence many different cellular functions.From theCambridge English Corpus
However, under nutrient limiting conditions in the environment, microorganisms may secrete ligands, such as siderophores, to scavenge trace metal micronutrients.From theCambridge English Corpus
However, the same trends in metal concentration and behaviour were observed in both biotic and abiotic components, indicating metal-specific ligands were not produced.From theCambridge English Corpus
In another possible application, these groups could be part of designed ligands, which may site-specifically penetrate the hydrophobic cores of proteins, possibly inactivating them.From theCambridge English Corpus
The option of facilitated transport of hydrophilic ligands to engage intracellular receptors is little used for signaling, however, suggesting that transmembrane receptors are more effective.From theCambridge English Corpus
What has largely failed is designing ligands based on known protein structure.From theCambridge English Corpus
Although there has been enormous progress toward accomplishing parts of the vision, the core problem - the design of ligands to bind proteins - has remained intractable.From theCambridge English Corpus
Overall, the interactions are characterised by enthalpy-entropy compensation mechanisms, as typically found for other groove-binding ligands.From theCambridge English Corpus
Acetylcholinesterase : role of the enzyme's charge distribution in steering charged ligands toward the active site.From theCambridge English Corpus
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