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单词 methylation
释义
methylation
noun[U]
chemistry,biologyspecialized
uk
/ˌmeθ.ɪˈleɪ.ʃən/us
/ˌmeθ.ɪˈleɪ.ʃən/
theprocessofaddingagroupofmethylatomsinto amoleculeorcompound:
甲基化
Early in thecourseof thedisease,cancerouscellsstartaccumulatingabnormalmethylation.在疾病早期，癌症细胞开始累积甲基化。
Manygenesundergoage-related methylation.许多基因会发生与年龄增长相关的甲基化。
See
methylate
More examples
  • Inbiologicalsystems, methylation isaccomplishedbyenzymes.
  • Maintenance of methylationpatternsisnecessaryfornormaldevelopmentofmice.
  • No methylation wasdetectedinbenigntissuefrombreastcancerpatients.
  • The methylationstatusof thegenedid notcorrelatewith thelevelsofprotein.
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Genetics
(Definition ofmethylationfrom theCambridge Advanced Learner's Dictionary & Thesaurus© Cambridge University Press)

Examplesofmethylation

methylation
However, antisense transcripts were still present after deletion and found to originate from other regions of maternalmethylation.
From theCambridge English Corpus
Our observations suggest an association between separation of parental chromosomes and differential activities ofmethylationand demethylation during early embryonic development of the mouse.
From theCambridge English Corpus
However, the exact mechanism and function ofmethylationchanges in such processes are substantially unknown.
From theCambridge English Corpus
Themethylationsites that survive are part of the imprinting process, passing maternal and paternal information to the final germ cell populations.
From theCambridge English Corpus
Hypo-methylationresults in the permanent overexpression of genes and is a feature of both aging25 and malignant cells.
From theCambridge English Corpus
Importantly, increasedmethylationwas also detectable in numerous premalignant lesions.
From theCambridge English Corpus
Amethylationassay with high specificity and sensitivity was developed, and a panel of breast tissue samples (n 175) was characterized for methylation status.
From theCambridge English Corpus
In eutherians, differentialmethylationof cis-regulatory regions is predominant.
From theCambridge English Corpus
Paramutation of the r1 locus of maize is associated with increased cytosinemethylation.
From theCambridge English Corpus
Imprintedmethylationand its effect on expression of the mouse zfp127 gene.
From theCambridge English Corpus
Here we used two drugs known to be involved (besides their side effects) in disturbance of the normal process ofmethylationstatus maintenance.
From theCambridge English Corpus
Such alterations are mediated bymethylationprocesses that are triggered by environmental events.
From theCambridge English Corpus
Methylationhas indeed been shown to accompany gene silencing in most of the mammalian, plant and filamentous fungal examples.
From theCambridge English Corpus
In addition to genetic changes, epigenetic alterations includingmethylationor imprinting could also lead to the somatic inactivation of candidate tumour suppressor genes.
From theCambridge English Corpus
In mature oligodendrocytes, the expression of inhibitory molecules is silenced by additional epigenetic modifications, including histonemethylationand chromatin compaction.
From theCambridge English Corpus
These examples are from corpora and from sources on the web. Any opinions in the examples do not represent the opinion of the Cambridge Dictionary editors or of Cambridge University Press or its licensors.
#https://dictionary.cambridge.org//dictionary/english/methylation##
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更新时间：2024/12/28 0:27:30