| 单词 | telomerase |
| 释义 | BETA Examples oftelomeraseDictionary> Examples oftelomerase telomeraseisn’t in the Cambridge Dictionary yet. You can help! Add a definition Thus, a detailed understanding oftelomeraseregulation will be required for any therapeutic applications. From theCambridge English Corpus Although the story is far from complete, several regulatory pathways have already been implicated in the normal and aberrant activity oftelomerasein human cells. From theCambridge English Corpus Alternatively, stimulated microglia undergo senescence, demonstrated by reduced viability and mitotic activity, after several weeks in culture and in the absence oftelomeraserepression. From theCambridge English Corpus However, these assays might fail to detect mixed populations oftelomerase-positive andtelomerase-negative cells in the tumour population (c). From theCambridge English Corpus Could these changes in structural conformation act as a molecular switch intelomerasefunction? From theCambridge English Corpus An important review of the rapid progress in understanding telomeres andtelomerasein health, disease (particularly cancer) and ageing. From theCambridge English Corpus Intelomerase-deficient mice, telomere shortening affects the function of epithelial stem cells. From theCambridge English Corpus However, several immortal cell lines and tumours lacktelomeraseactivity, yet have the ability to elongate their telomeres. From theCambridge English Corpus Furthermore, small-cell lung cancer shows high levels and frequency oftelomeraseactivity and gene expression. From theCambridge English Corpus This suggests a model by which epigenetic deregulation of thetelomerasegene promoters could lead to aberrant telomere maintenance. From theCambridge English Corpus It is now clear that the enzymetelomeraseconfers immortality on cells in most types of cancer. From theCambridge English Corpus The early clinical evaluation oftelomerase-based therapeutics presents specific challenges and requires the design of appropriate models for preclinical evaluation. From theCambridge English Corpus Once activated,telomerasemaintains telomeres at a length compatible with cell proliferation through the addition of telomere repeat sequences. From theCambridge English Corpus Inhibition of cell proliferation was observed only after a lag period and, importantly, only intelomerase-positive cells. From theCambridge English Corpus I t is anticipated that classicaltelomeraseinhibitors will ultimately have their greatest clinical impact in 'minimal disease states'. From theCambridge English Corpus There are now numerous assays to test fortelomeraseactivity, enabling tumours to be tested for suitability fortelomerasetherapy. From theCambridge English Corpus This puts the therapeutic effects oftelomerase-derived therapies into perspective. From theCambridge English Corpus The induction oftelomeraseexpression appears to be a key event in immortalisation. From theCambridge English Corpus Expression oftelomerasewould avoid this catastrophic series of events. From theCambridge English Corpus These examples are from corpora and from sources on the web. Any opinions in the examples do not represent the opinion of the Cambridge Dictionary editors or of Cambridge University Press or its licensors. |
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