It was found that the compoundtrinitrotoluenecould easily be split into its elements and toluene would result.
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Nitration reactions are notably used for the production of explosives, for example the conversion of guanidine to nitroguanidine and the conversion of toluene totrinitrotoluene.
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Blood and liver effects, spleen enlargement and other harmful effects on the immune system have also been found in animals that ingested or breathedtrinitrotoluene.
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For example, 2,4,6-trinitrotolueneis oxidized to the corresponding carboxylic acid.
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Examples of materials with negative oxygen balance are e.g.trinitrotoluene(-74%), aluminium powder (-89%), sulfur (-100%), or carbon (-266.7%).
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Drugs associated with sulfhemoglobinemia include acetanilid, phenacetin, nitrates,trinitrotolueneand sulfur compounds (mainly sulphonamides, sulfasalazine).
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Mixtures of ordinary nitric acid in sulfuric acid therefore contain substantial amounts of water and are unsuitable for processes such as occur in the manufacture oftrinitrotoluene.
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