tumor suppressor gene

collocation in English

meaningsoftumour,suppressorandgene

These words are often used together. Click on the links below to explore the meanings. Or,see other collocations withgene.
tumour
noun[C]
uk
/ˈtʃuː.mər/us
/ˈtuː.mɚ/
a mass of diseased cells that might become a lump or ...
See more attumour
suppressor
noun[C]
uk
/səˈpres.ər/us
/səˈpres.ɚ/
a thing or person that prevents something bad ...
See more atsuppressor
gene
noun[C]
uk
/dʒiːn/us
/dʒiːn/
a part of the DNA in a cell that controls the physical development, behaviour, etc. of an individual plant or animal and is passed on from ...
See more atgene

(Definition oftumour,suppressorandgenefrom theCambridge English Dictionary© Cambridge University Press)

Examplesoftumor suppressor gene

These examples are from corpora and from sources on the web. Any opinions in the examples do not represent the opinion of the Cambridge Dictionary editors or of Cambridge University Press or its licensors.
Pathogenesis of persistent hyperplastic primary vitreous in mice lacking the arf tumorsuppressorgene.
From theCambridge English Corpus
This is characteristic of a tumoursuppressorgene.
From theCambridge English Corpus
Loss of 22q has been found in both sporadic and familial cases, supporting the presence of a tumorsuppressorgeneat this location.
From
Wikipedia
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This gene is frequently mutated or deleted in a wide variety of tumors and is known to be an important tumorsuppressorgene.
From
Wikipedia
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The p53 (a tumorsuppressorgenein the normal population) genome on 17p in neurofibrosarcoma patients is mutated, increasing the probability of cancer.
From
Wikipedia
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Despite regulation by tumorsuppressorgenep53, loss-of-function mutations in p21 (unlike p53) do not accumulate in cancer nor do they predispose to cancer incidence.
From
Wikipedia
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They contain no functional p53, a potent tumorsuppressorgene, and so are highly sensitive to mitogenic stimuli.
From
Wikipedia
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It can behave as a tumoursuppressorgene.
From
Wikipedia
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The expression of this gene is reported to be downregulated in colorectal carcinoma tissue suggesting that is a candidate tumorsuppressorgene.
From
Wikipedia
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However, cases exist in which one mutated copy of a tumorsuppressorgenecan render the other, wild-type copy non-functional.
From
Wikipedia
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When both copies of a tumorsuppressorgene(e.g. p53 gene) are mutated, cells lose their ability to stop dividing even when they should.
From
Wikipedia
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Nonetheless, it is suspected to act as a tumorsuppressorgene.
From
Wikipedia
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However, a mutation can damage the tumorsuppressorgeneitself, or the signal pathway that activates it, switching it off.
From
Wikipedia
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An innate genomic deficit in a tumorsuppressorgeneimpairs normal responses and exacerbates the susceptibility to disease in organ targets.
From
Wikipedia
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Though its function is not fully understood, it appears to be a tumorsuppressorgenethat restricts cell growth and division.
From
Wikipedia
This example is from Wikipedia and may be reused under a CC BY-SA license.
This gene is located in the tumorsuppressorgeneregion on chromosome 3p21.3 and the encoded protein may play a role in cancer.
From
Wikipedia
This example is from Wikipedia and may be reused under a CC BY-SA license.
It acts as a tumorsuppressorgeneto inhibit cell growth and proliferation as well as induce apoptosis when a cell is under stress.
From
Wikipedia
This example is from Wikipedia and may be reused under a CC BY-SA license.
These examples are from corpora and from sources on the web. Any opinions in the examples do not represent the opinion of the Cambridge Dictionary editors or of Cambridge University Press or its licensors.
Want to learn more?
Go to the definition oftumour
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Go to the definition ofgene
See other collocations withgene