This will need to be established using animal models that produce low baseline glucocorticoid concentrations without removing glucocorticoids entirely from systemic circulation (as is the case inadrenalectomy).
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During this process one or two adrenal glands can be removed and this is known asadrenalectomy.
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Followingadrenalectomy, epinephrine disappears below the detection limit in the blood stream.
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Bilateraladrenalectomyis another treatment which provides immediate reduction of cortisol level and control of hypercortisolism.
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All of these conditions, with the exception ofadrenalectomy, cause a large elevation of circulating aldosterone.
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