Spontaneous diabetes mellitus in transgenic mice expressing human isletamyloidpolypeptide.From theCambridge English Corpus
Although the b-helix is a plausible structural motif foramyloidfibrils, it has not yet been proven that bona fide b-helices occur in amyloid fibrils.From theCambridge English Corpus
Detailed structural information has been difficult to obtain by conventional techniques because of the inherent non-crystalline and insoluble nature ofamyloidfibrils.From theCambridge English Corpus
These models were antiparallel b-helices, presumably because the more common occurrence of parallel b-sheets inamyloidfibrils had not yet been established.From theCambridge English Corpus
Xray analysis suggests that a protofilament in thisamyloidis composed of a single pair of -sheets in the normal cross- conformation.From theCambridge English Corpus
This latter reflection, of course, can only occur if theamyloidfibrils, or protofilaments, are composed of two or more -sheets.From theCambridge English Corpus
Synthetic peptides homologous to prion protein residues 106-147 formamyloid-like fibrils in vitro.From theCambridge English Corpus
The oligomerization ofamyloidbeta-protein begins intracellularly in cells derived from human brain.From theCambridge English Corpus
Insulin-degrading enzyme regulates extracellular levels ofamyloidbeta-protein by degradation.From theCambridge English Corpus
Thus, there are no absolutely universal molecular structural features inamyloidfibrils, apart from the cross-b motif.From theCambridge English Corpus
The larger number of equatorial reflections reflect the presence of protofilaments inamyloidfibrils.From theCambridge English Corpus
Once formed,amyloidstructures are not dependent on the presence of mobile water and are not significantly distorted when mobile water is removed by lyophilization.From theCambridge English Corpus
Partial denaturation of transthyretin is sufficient foramyloidfibril formation in vitro.From theCambridge English Corpus
This review will focus on in vitro studies aimed at the characterization of an intermediate on theamyloidpathway as one potential toxic species.From theCambridge English Corpus
Conducting nanowires built by controlled self-assembly ofamyloidfibers and selective metal deposition.From theCambridge English Corpus
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