The cumulative inactivation of tumour suppressor genes and/or the amplification of oncogenes lead to progressively more malignant astrocytic tumours.
From theCambridge English Corpus
Unravelling the molecular basis ofoncogeneco-operation has lagged far behind its conceptual realisation.
From theCambridge English Corpus
These steps include inactivation of tumour suppressor genes and activation of oncogenes.
From theCambridge English Corpus
These two nuclear proto-oncogenes encode proteins that play central roles in intracellular signal transduction pathways.
From theCambridge English Corpus
In fact, the prolific field of signal transduction was born out ofoncogeneresearch.
From theCambridge English Corpus
But, with a more-detailed knowledge about the signalling pathways that are influenced by oncogenes, this question is rapidly becoming a focus again.
From theCambridge English Corpus
Most established cell lines are efficiently transformed by a singleoncogene.
From theCambridge English Corpus
By contrast, the activation of oncogenes is dominant in that a change in only one copy of the gene will have an effect.
From theCambridge English Corpus
However, a strong synergism between the v-raf and v-myc oncogenes was revealed.
From theCambridge English Corpus
Failure of these pathways can result in the loss of control over proliferation and lead to tumour development through the inactivation of tumour suppressor genes or the activation of oncogenes.
From theCambridge English Corpus
His work on a particularoncogeneis very important in developing new strategies to tackle the rogue cells of cancer.
From the
Hansard archive
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Loss of that methylation can induce the aberrant expression of oncogenes, leading to cancer pathogenesis.
From
Wikipedia
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