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Examples ofmisfolded
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Misfoldedstructures can be stable, and kinetically trapped species often transiently accumulate in refolding experiments.
From theCambridge English Corpus
Is there 'plasticity' in the folding process upon interaction of themisfoldedprotein with a pharmacological chaperone?
From theCambridge English Corpus
It is likely that neurotoxicity is caused by themisfoldedprotein in its soluble form, and/or in aggregates, and/or in the process of aggregation.
From theCambridge English Corpus
Protein misfolding: optional barriers,misfoldedintermediates, and pathway heterogeneity.
From theCambridge English Corpus
The formation of illegitimate sulfide bonds creates amisfoldedprotein, resulting in loss of function.
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This example is from Wikipedia and may be reused under a CC BY-SA license.
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This example is from Wikipedia and may be reused under a CC BY-SA license.The affected protein may bemisfoldedor truncated, or it may contain an expanded repeat or amino acid substitution.
From theCambridge English Corpus
The multivalent nature of this binding could potentially contribute to reversingmisfoldedstates.
From theCambridge English Corpus
Exactly how themisfoldedproteins trigger oligodendrocyte apoptosis and why they are harmful to the cell is currently uncertain.
From theCambridge English Corpus
The other path involves a species that ismisfoldedand has to rearrange in an even slower step before the properly folded structure is reached.
From theCambridge English Corpus
Interactions involving the exposed hydrophobic surfaces ofmisfoldedprotein conformers lead to the formation of toxic aggregates, including oligomers, protofibrils and amyloid fibrils.
From theCambridge English Corpus
The red asterisk represents a site of modification on themisfoldedprotein as a result of one of these stresses.
From theCambridge English Corpus
In some cases, chaperones promote the correct folding of theirmisfoldedprotein substrates.
From theCambridge English Corpus
Complex formation with the chaperone thus allows the correction ofmisfoldedconformations in an isolated environment without the danger of intermolecular aggregation reactions.
From theCambridge English Corpus
Strikingly, the transgenic rats showed thatmisfoldedprotein tau triggered massive inflammatory response characterized by activation of microglia and macrophages.
From theCambridge English Corpus
Moreover, paths that lead tomisfolded, kinetically trapped species can also be seen.
From theCambridge English Corpus
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