The pathways through which mammalian cells maintaintelomerestability are beginning to come into focus.From theCambridge English Corpus
This view has greater credibility now that biological age can be measured 'scientifically' by, for example,telomerelength.From theCambridge English Corpus
The choice oftelomeremaintenance mechanism may be influenced through epigenetic mechanisms and changes in histone modifications, possibly during tumourigenesis.From theCambridge English Corpus
Early growth determines longevity in male rats and may be related totelomereshortening in the kidney.From theCambridge English Corpus
Therefore, the role oftelomereshortening in mice is likely not to have the same relevance as in humans.From theCambridge English Corpus
However, further studies are needed to develop, or disprove, a link between telomeres, cell replication and longevity.From theCambridge English Corpus
If you are searching for papers on the role of mitochondria, telomeres or epigenetics in cloning the papers are cited here in separate lists.From theCambridge English Corpus
Cellular senescence as a response totelomereattrition is thought to have evolved as a tumour suppressive barrier against excessive clonal expansion.From theCambridge English Corpus
There is also an increasing awareness of the role thattelomerelength contributes to human genetic diseases.From theCambridge English Corpus
Telomereshortening is associated with cell division in vitro and in vivo.From theCambridge English Corpus
Additionally, studies have shown that microglia in vivo experience an age-related decrease intelomerelength.From theCambridge English Corpus
Most interesting are thetelomererepeats, as they have what few other non-genic repetitive sequences have : an accepted biological rationale.From theCambridge English Corpus
The more recent investigations intotelomere-shortening have included liver tissue, and might provide information about the nature of the aging process itself.From theCambridge English Corpus
One theory used to explain the mechanism is that oftelomereshortening.From theCambridge English Corpus
However, several immortal cell lines and tumours lack telomerase activity, yet have the ability to elongate their telomeres.From theCambridge English Corpus
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