The symptoms associated withmyelofibrosisare variable and in more than 50% of patients include marked lassitude, loss of weight and night sweats.
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This distinction is important since the treatment of polycythemia vera carries a serious risk ofmyelofibrosisand acute leukemia.
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A leucoerythroblastic blood film, where nucleated red blood cells and early white cell forms appear, is strongly suggestive ofmyelofibrosisor marrow replacement by malignancy (both haematological and non-haematological).
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The cause and risk factors for primarymyelofibrosisare unknown.
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Myelofibrosisis a myeloid malignancy associated with anemia, splenomegaly, and constitutional symptoms.
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It is common in people who have chronic idiopathicmyelofibrosis.
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It is part of the presentation in acute panmyelosis withmyelofibrosis.
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Older terms includemyelofibrosiswith myeloid metaplasia and agnogenic myeloid metaplasia.
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For the disease chronic idiopathicmyelofibrosis, seemyelofibrosis.
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Hairy cell leukemia was originally described as histiocytic leukemia, malignant reticulosis, or lymphoidmyelofibrosisin publications dating back to the 1920s.
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Dacrocytosis can be associated with myelophthisic anemia, commonly caused bymyelofibrosis.
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Seen in bone marrow failure,myelofibrosisand extramedullary haemopoiesis.
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Myelofibrosisis a form of myeloid metaplasia, and often the two terms are used synonymously.
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She currently suffers frommyelofibrosis, a bone-marrow disorder that affects the red blood cells.
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In primarymyelofibrosis, progressive scarring (fibrosis) of the bone marrow occurs, for the reasons discussed above.
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